Groeger, Kathrin; Baretic, Domagoj; Piantanida, Ivo; Marjanovic, Marko; Kralj, Marijeta; Grabar, Marina; Tomic, Sanja; Schmuck, Carsten published an article about the compound: Ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate hydrochloride( cas:180258-46-2,SMILESS:O=C(C1=NC(N)=CN1C)OCC.[H]Cl ).Electric Literature of C7H12ClN3O2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:180258-46-2) through the article.
Two novel guanidiniocarbonyl pyrrole-pyrene conjugates III and IV as spectroscopic probes for ds-polynucleotides were synthesized and their interaction with different ds-DNAs/RNAs studied. Compared to a previously reported first set of conjugates (I and II) the significant extension and increased rigidity of the central part of the structure resulted in a switch of DNA binding mode from intercalative (previously studied derivatives I and II with a nonbinding and flexible linker) to minor groove binding of the two novel guanidiniocarbonyl-pyrrole-pyrene conjugates III and IV. These two compounds interact strongly with ds-DNAs, but only weakly with ds-RNA. The newly incorporated heterocyclic moieties within the central part of the structure of III and IV were able to control by steric and hydrogen-bonding effects the alignment of the mols. within various, structurally different forms of DNA minor grooves, whereby even small differences in the position of the attached pyrene within the groove were reflected in different fluorimetric responses. In addition, III and IV revealed intriguing in vitro selectivity among various human tumor cell lines.
Although many compounds look similar to this compound(180258-46-2)Electric Literature of C7H12ClN3O2, numerous studies have shown that this compound(SMILES:O=C(C1=NC(N)=CN1C)OCC.[H]Cl), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com