Recommanded Product: Sodium ((4-aminophenyl)sulfonyl)(6-chloropyrazin-2-yl)amide. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Sodium ((4-aminophenyl)sulfonyl)(6-chloropyrazin-2-yl)amide, is researched, Molecular C10H8ClN4NaO2S, CAS is 23307-72-4, about Study of the interaction between sodium salts of (2E)-3-(4′-halophenyl)prop-2-enoyl sulfachloropyrazine and bovine serum albumin by fluorescence spectroscopy.
Three sodium salts of (2E)-3-(4′-halophenyl)prop-2-enoyl sulfachloropyrazine (CCSCP) were synthesized and their structures were determined by 1H and 13C NMR, LC-MS and IR. The binding properties between CCSCPs and bovine serum albumin (BSA) were studied using fluorescence spectroscopy in combination with UV-vis absorbance spectroscopy. The results indicate that the fluorescence quenching mechanisms between BSA and CCSCPs were static quenching at low concentrations of CCSCPs or combined quenching (static and dynamic) at higher CCSCP concentrations of 298, 303 and 308 K. The binding constants, binding sites and corresponding thermodn. parameters (ΔH, ΔS, ΔG) were calculated at different temperatures All ΔG values were neg., which revealed that the binding processes were spontaneous. Although all CCSCPs had neg. ΔH and pos. ΔS, the contributions of ΔH and ΔS to ΔG values were different. When the 4′-substituent was fluorine or chlorine, van der Waals interactions and hydrogen bonds were the main interaction forces. However, when the halogen was bromine, ionic interaction and proton transfer controlled the overall energetics. The binding distances between CCSCPs and BSA were determined using the Foerster non-radiation energy transfer theory and the effects of CCSCPs on the conformation of BSA were analyzed by synchronous fluorescence spectroscopy. Copyright © 2012 John Wiley & Sons, Ltd.
Although many compounds look similar to this compound(23307-72-4)Recommanded Product: Sodium ((4-aminophenyl)sulfonyl)(6-chloropyrazin-2-yl)amide, numerous studies have shown that this compound(SMILES:ClC1=CN=CC([N-]S(=O)(C2=CC=C(N)C=C2)=O)=N1.[Na+]), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com