Name: (2S)-(+)-3-Chloropropane-1,2-diol. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: (2S)-(+)-3-Chloropropane-1,2-diol, is researched, Molecular C3H7ClO2, CAS is 60827-45-4, about Formation of the active antifertility metabolite of (S)-α-chlorohydrin in boar sperm. Author is Jones, A. R.; Stevenson, D..
Incubation of boar sperm with (S)-α-chlorohydrin (I) [60827-45-4] resulted in formation of (S)-3-chlorolactaldehyde (II) [86747-03-7]. I inhibited the production of 14CO2 when 14C-labeled fructose [57-48-7] was the substrate but had no effect when 14C-labeled glycerol [56-81-5] was used. (R,S)-3-Chlorolactaldehyde [84709-24-0], however, inhibited CO2 formation from glycerol. The oxidation of 14C-labeled glycerol-3-phosphate [57-03-4] was similarly inhibited by I confirming that the presence of glycerol but not its metabolites prevented the oxidation of I to II. Glycerol reversed the inhibition of fructose metab by I. Addnl., preincubation of sperm with I inhibited glycerol metabolism Apparently, I is metabolized to II in sperm by an enzyme involved in the oxidation of glycerol to glyceraldehyde. The presence of glycerol decreases the activity of this enzyme towards I thereby preventing formation of II, an inhibitor of glyceraldehyde 3-phosphate dehydrogenase [9001-50-7].
Although many compounds look similar to this compound(60827-45-4)Name: (2S)-(+)-3-Chloropropane-1,2-diol, numerous studies have shown that this compound(SMILES:OC[C@H](O)CCl), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com