Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 60827-45-4, is researched, SMILESS is OC[C@H](O)CCl, Molecular C3H7ClO2Journal, Article, Research Support, Non-U.S. Gov’t, Australian Journal of Biological Sciences called Inhibition of fructolysis in boar spermatozoa by the male antifertility agent (S)-α-chlorohydrin, Author is Stevenson, Denise; Jones, A. R., the main research direction is fructose metabolism sperm chlorohydrin.Quality Control of (2S)-(+)-3-Chloropropane-1,2-diol.
The male antifertility agent (S)-α-chlorohydrin [60827-45-4] strongly inhibited the oxidative metabolism of fructose [57-48-7] by boar spermatozoa in vitro. The result of this action, which has been deduced to be an inhibition of glyceraldehyde phosphate dehydrogenase, caused an accumulation of fructose 1,6-bisphosphate [488-69-7] and the triose phosphates, and a decrease in substrate-level phosphorylation with a concomitant lowering of the energy charge potential of the spermatozoa. (R)-α-chlorohydrin [57090-45-6] Had no inhibitory activity on fructolysis. A study of the comparative metabolism of (R)-[3-36Cl]-α-chlorohydrin and (R,S)-[3-36Cl]-α-chlorohydrin by boar spermatozoa showed that it is the (S)-isomer that specifically undergoes a process of oxidative metabolism to (R)-3-chlorolactaldehyde [84607-54-5]. This endogenous oxidation product, which has the same absolute configuration as the substrate for glyceraldehyde phosphate dehydrogenase, may be the active metabolite of (S)-α-chlorohydrin that inhibits this enzyme. Exogenous (R,S)-3-chlorolactaldehyde [84709-24-0] inhibited the oxidative metabolism of fructose by boar spermatozoa, apparently by a mechanism similar to that of (S)-α-chlorohydrin.
In some applications, this compound(60827-45-4)Quality Control of (2S)-(+)-3-Chloropropane-1,2-diol is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com