The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (S)-4-Benzyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole, is researched, Molecular C19H16N2O, CAS is 2058236-52-3, about Enantioselective Construction of α-Chiral Silanes by Nickel-Catalyzed C(sp3)-C(sp3) Cross-Coupling, the main research direction is alpha silylated alkyl iodide cross coupling alkylzinc reagent; enantioselective alpha chiral silane preparation nickel catalyzed coupling; nickel benzyl Pybox catalyzed enantioselective coupling alpha silylated iodoalkane; cross-coupling; nickel; radical reactions; silicon; synthetic methods.Related Products of 2058236-52-3.
An enantioselective C(sp3)-C(sp3) cross-coupling of racemic α-silylated alkyl iodides and alkylzinc reagents is reported. The reaction is catalyzed by NiCl2/(S,S)-Bn-Pybox and yields α-chiral silanes with high enantiocontrol. The catalyst system does not promote the cross-coupling of the corresponding carbon analog, corroborating the stabilizing effect of the silyl group on the alkyl radical intermediate (α-silicon effect). Both coupling partners can be, but do not need to be, functionalized, and hence, even α-chiral silanes with no functional group in direct proximity of the asym. substituted carbon atom become accessible. This distinguishes the new method from established approaches for the synthesis of α-chiral silanes.
In some applications, this compound(2058236-52-3)Related Products of 2058236-52-3 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com