Jackson, H.; Rooney, F. R.; Fitzpatrick, R. W.; Gibson, K. H. published the article 《Characterization and antifertility activity in rats of S(+)-α-chlorohydrin》. Keywords: chlorohydrin stereoisomer antifertility activity.They researched the compound: (2S)-(+)-3-Chloropropane-1,2-diol( cas:60827-45-4 ).HPLC of Formula: 60827-45-4. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:60827-45-4) here.
In male rats, a single oral dose of S(+)α-chlorohydrin (I) [60827-45-4] (12.5 mg/kg) produced temporary infertility following pairing with females from matings between days 2 and 6 after the I dose. A similar dose of the racemic mixture [96-24-2] was ineffective and the antifertility effect of the active isomer was comparable to that produced by a mixture of similar amounts of the S(+)- and R(-) [57090-45-6]-isomer or the corresponding dose of the racemate (25 mg/kg). However, the latter dose of the S(+)-isomer induced sterility during week 1, some degree of recovery of fertility in weeks 2-3 followed by permanent sterility. The S(+) isomer also maintained the reversible antifertility effect on epididymal spermatozoa at a daily oral dose of 5-10 mg/kg. Preparation of derivatives of I may provide compounds with high antifertility potency and low toxicity.
In some applications, this compound(60827-45-4)HPLC of Formula: 60827-45-4 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com