So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Bredikhina, Zemfira A.; Kurenkov, Alexey V.; Krivolapov, Dmitry B.; Bredikhin, Alexander A. researched the compound: (2S)-(+)-3-Chloropropane-1,2-diol( cas:60827-45-4 ).Recommanded Product: 60827-45-4.They published the article 《Stereoselective crystallization of 3-(2,6-dimethylphenoxy)propane-1,2-diol: preparation of the single-enantiomer drug mexiletine》 about this compound( cas:60827-45-4 ) in Tetrahedron: Asymmetry. Keywords: crystallization dimethylphenoxypropanediol enantiomer drug mexiletine. We’ll tell you more about this compound (cas:60827-45-4).
Racemic 3-(2,6-dimethylphenoxy)propane-1,2-diol 8 undergoes spontaneous resolution upon crystallization This fact is confirmed by the m.p. inspection, vibration spectra and X-ray single crystal diffraction of racemic and scalemic crystalline samples of 8. Racemic 8 has been effectively resolved by a preferential crystallization procedure into (S)- and (R)-enantiomers with ee of approx. 90%. The enantiomeric purity of (S)- and (R)-8 could be increased to ee >99% through simple recrystallization Nonracemic diols 8 were converted into nonracemic 1,2-epoxy-3-(2,6-dimethylphenoxy)propanes (S)- and (R)-7 with ee 98% via Mitsunobu reaction. The reaction proceeded without loss of enantiomeric purity, and the initial configuration of the stereogenic center was conserved. Enantiopure epoxides 7 were converted into nonracemic 1-(2,6-dimethylphenoxy)propan-2-ols 2, which are valuable intermediates in single-enantiomer mexiletine synthesis.
In addition to the literature in the link below, there is a lot of literature about this compound((2S)-(+)-3-Chloropropane-1,2-diol)Recommanded Product: 60827-45-4, illustrating the importance and wide applicability of this compound(60827-45-4).
Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com