Recommanded Product: (2S)-(+)-3-Chloropropane-1,2-diol. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (2S)-(+)-3-Chloropropane-1,2-diol, is researched, Molecular C3H7ClO2, CAS is 60827-45-4, about Inhibitory effect of (s)-chlorohydrin on rat sperm motility and hyperactivation. Author is Zhang, Hao; Zheng, Weiwei; Wang, Xia; Liu, Li; Qu, Weidong.
The effects of (S)-α-chlorohydrin (SACH) on rat epididymal sperm motility and hyperactivation and the mechanisms of the effects were studied. 20 Adult male Sprague-Dawley rats were divided randomly into 4 groups and dosed orally with 0, 2.5, 5.0, and 10mg/kg BW SACH for 52 days. After the cauda epididymal sperm were incubated under a capacitating condition for 5h, sperm motility and hyperactivation parameters were obtained by computer-assisted sperm anal. (CASA), and sperm-specific glyceraldehyde 3-phosphate dehydrogenase (GAPDS) activity, ATP (ATP), and cyclic adenosine monophosphate (cAMP) were assayed. The protecting effect of pentoxifylline (PTF) against SACH was also tested. The sperm from the SACH-treated rats showed significant decreases in curvilinear velocity (VCL), average path velocity (VAP), straight line velocity (VSL), and amplitude of lateral head movement (ALH) (P<0.01 of all), and an increase in linearity (LIN) (P<0.01). The SACH-treated rats had much less sperm population with VCL≥400μm/s or LIN≤20% than that of the control (P<0.05 and P<0.01, resp.), indicating that SACH diminishes hyperactivation of rat sperm. GAPDS activities were inhibited by SACH, and decreasing trends of ATP and cAMP levels were observed PTF rescued the cAMP level which was depressed by SACH, and alleviated partly the inhibition of sperm motility and hyperactivation. SACH impairs the motility and hyperactivation of rat sperm, which might be related to inhibition of GAPDS by SACH and subsequent defects of ATP and cAMP. Here is just a brief introduction to this compound(60827-45-4)Recommanded Product: (2S)-(+)-3-Chloropropane-1,2-diol, more information about the compound((2S)-(+)-3-Chloropropane-1,2-diol) is in the article, you can click the link below.
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