Chenoweth, David M.; Harki, Daniel A.; Dervan, Peter B. published the article 《Solution-Phase Synthesis of Pyrrole-Imidazole Polyamides》. Keywords: pyrrole imidazole polyamide oligomeric solution phase synthesis.They researched the compound: Ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate hydrochloride( cas:180258-46-2 ).Application In Synthesis of Ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate hydrochloride. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:180258-46-2) here.
A solution-phase alternative to typical solid-phase synthesis of pyrrole-imidazole polyamides, which are DNA-binding mols. programmable for a large repertoire of DNA sequences, is reported. An 8-ring hairpin polyamide, which targets the DNA sequence 5′-WGWWCW-3′, was chosen for this synthesis as this oligomer exhibits androgen receptor antagonism in cell culture models of prostate cancer. A convergent solution-phase synthesis of this polyamide from a small set of com. available building blocks presented highlights principles for preparing gram quantities of pyrrole-imidazole oligomers with minimal chromatog.
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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com