Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 23307-72-4, is researched, SMILESS is ClC1=CN=CC([N-]S(=O)(C2=CC=C(N)C=C2)=O)=N1.[Na+], Molecular C10H8ClN4NaO2SJournal, Article, Research Support, Non-U.S. Gov’t, Luminescence called Study of the interaction between sodium salts of (2E)-3-(4′-halophenyl)prop-2-enoyl sulfachloropyrazine and bovine serum albumin by fluorescence spectroscopy, Author is Luo, Xuan; Du, Chuanrong; Wei, Jinrui; Deng, Jiang; Lin, Yijie; Lin, Cuiwu, the main research direction is fluorescence spectroscopy bovine serum albumin CCSCP sodium salt.Computed Properties of C10H8ClN4NaO2S.
Three sodium salts of (2E)-3-(4′-halophenyl)prop-2-enoyl sulfachloropyrazine (CCSCP) were synthesized and their structures were determined by 1H and 13C NMR, LC-MS and IR. The binding properties between CCSCPs and bovine serum albumin (BSA) were studied using fluorescence spectroscopy in combination with UV-vis absorbance spectroscopy. The results indicate that the fluorescence quenching mechanisms between BSA and CCSCPs were static quenching at low concentrations of CCSCPs or combined quenching (static and dynamic) at higher CCSCP concentrations of 298, 303 and 308 K. The binding constants, binding sites and corresponding thermodn. parameters (ΔH, ΔS, ΔG) were calculated at different temperatures All ΔG values were neg., which revealed that the binding processes were spontaneous. Although all CCSCPs had neg. ΔH and pos. ΔS, the contributions of ΔH and ΔS to ΔG values were different. When the 4′-substituent was fluorine or chlorine, van der Waals interactions and hydrogen bonds were the main interaction forces. However, when the halogen was bromine, ionic interaction and proton transfer controlled the overall energetics. The binding distances between CCSCPs and BSA were determined using the Foerster non-radiation energy transfer theory and the effects of CCSCPs on the conformation of BSA were analyzed by synchronous fluorescence spectroscopy. Copyright © 2012 John Wiley & Sons, Ltd.
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Reference:
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