The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (S)-4-Benzyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole( cas:2058236-52-3 ) is researched.Name: (S)-4-Benzyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole.Yi, Hong; Mao, Wenbin; Oestreich, Martin published the article 《Enantioselective Construction of α-Chiral Silanes by Nickel-Catalyzed C(sp3)-C(sp3) Cross-Coupling》 about this compound( cas:2058236-52-3 ) in Angewandte Chemie, International Edition. Keywords: alpha silylated alkyl iodide cross coupling alkylzinc reagent; enantioselective alpha chiral silane preparation nickel catalyzed coupling; nickel benzyl Pybox catalyzed enantioselective coupling alpha silylated iodoalkane; cross-coupling; nickel; radical reactions; silicon; synthetic methods. Let’s learn more about this compound (cas:2058236-52-3).
An enantioselective C(sp3)-C(sp3) cross-coupling of racemic α-silylated alkyl iodides and alkylzinc reagents is reported. The reaction is catalyzed by NiCl2/(S,S)-Bn-Pybox and yields α-chiral silanes with high enantiocontrol. The catalyst system does not promote the cross-coupling of the corresponding carbon analog, corroborating the stabilizing effect of the silyl group on the alkyl radical intermediate (α-silicon effect). Both coupling partners can be, but do not need to be, functionalized, and hence, even α-chiral silanes with no functional group in direct proximity of the asym. substituted carbon atom become accessible. This distinguishes the new method from established approaches for the synthesis of α-chiral silanes.
If you want to learn more about this compound((S)-4-Benzyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole)Name: (S)-4-Benzyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(2058236-52-3).
Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com