So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Stevenson, D.; Jones, A. R. researched the compound: (2S)-(+)-3-Chloropropane-1,2-diol( cas:60827-45-4 ).Synthetic Route of C3H7ClO2.They published the article 《Production of (S)-3-chlorolactaldehyde from (S)-α-chlorohydrin by boar spermatozoa and the inhibition of glyceraldehyde 3-phosphate dehydrogenase in vitro》 about this compound( cas:60827-45-4 ) in Journal of Reproduction and Fertility. Keywords: chlorolactaldehyde formation chlorohydrin sperm. We’ll tell you more about this compound (cas:60827-45-4).
The male antifertility agent (S)-α-chlorohydrin [60827-45-4] was metabolized by mature boar spermatozoa in vitro to (S)-3-chlorolactaldehyde [86747-03-7]. This oxidative process, which did not occur when (R)-α-chlorohydrin was offered as a substrate, was catalyzed by an NADP-dependent dehydrogenase that converts glycerol [56-81-5] to glyceraldehyde. (S)-3-Chlorolactaldehyde, produced by this metabolic reaction or when added to suspensions of boar spermatozoa, was a specific inhibitor of glyceraldehyde 3-phosphate dehydrogenase [9028-92-6] as assessed by the accumulation of fructose 1,6-diphosphate and the triose phosphates. When glycerol and (S)-α-chlorohydrin were added concomitantly to boar spermatozoa in vitro, the presence of glycerol decreased the degree of inhibition of glyceraldehyde 3-phosphate dehydrogenase. Extracts of glyceraldehyde 3-phosphate dehydrogenase that were obtained from boar spermatozoa incubated with (S)-α-chlorohydrin or (R,S)-3-chlorolactaldehyde [84709-24-0] showed significant reductions in their enzymic activity.
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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com