The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The antiglycolytic action of (S)-α-chlorohydrin on epididymal bovine spermatozoa in vitro》. Authors are Jones, A. R.; Du Toit, J. I..The article about the compound:(2S)-(+)-3-Chloropropane-1,2-diolcas:60827-45-4,SMILESS:OC[C@H](O)CCl).Quality Control of (2S)-(+)-3-Chloropropane-1,2-diol. Through the article, more information about this compound (cas:60827-45-4) is conveyed.
(S)-α-Chlorohydrin [60827-45-4] interferes with glycolysis in bovine spermatozoa, whereas the (R)-isomer is ineffective. The action of the (S)-isomer, which involves inhibition of the reaction catalyzed by glyceraldehyde-3-phosphate dehydrogenase [9001-50-7], is not immediate but is evident only after a brief period of incubation with the spermatozoa. This inhibitory action is prevented when glycerol [56-81-5] is present, suggesting that the mechanism of action of (S)-α-chlorohydrin requires its oxidation to (S)-3-chlorolactaldehyde [86747-03-7], which is the active metabolite. Addition of (R,S)-3-chlorolactaldehyde [84709-24-0] to bovine spermatozoa caused immediate inhibition of glycolysis. The action of (S)-α-chlorohydrin in bovine spermatozoa may be similar to that observed in the spermatozoa of other species in being a 2-stage process: 1st, its oxidation to (S)-3-chlorolactaldehyde, and then inhibition of the glycolytic enzyme by this metabolite.
Compound(60827-45-4)Quality Control of (2S)-(+)-3-Chloropropane-1,2-diol received a lot of attention, and I have introduced some compounds in other articles, similar to this compound((2S)-(+)-3-Chloropropane-1,2-diol), if you are interested, you can check out my other related articles.
Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com