Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (2S)-(+)-3-Chloropropane-1,2-diol, is researched, Molecular C3H7ClO2, CAS is 60827-45-4, about A formal synthesis of (+)-α-allokainic acid via sulfanyl radical addition-cyclization reaction.Synthetic Route of C3H7ClO2.
Sulfanyl radical addition-cyclization of diallylamine I in the presence of thiophenol and AIBN gave the 2,3,4-trisubstituted pyrrolidines II (R = PhSCH2, R1 = H; R = H, R1 = PhSCH2) which were effectively converted into the known key intermediate for the synthesis of (+)-α-allokainic acid via conversion of the phenylsulfanylmethyl group into the isopropenyl group at the 4-position.
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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com