Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate hydrochloride, is researched, Molecular C7H12ClN3O2, CAS is 180258-46-2, about Guanidiniocarbonyl-pyrrole-aryl conjugates as nucleic acid sensors: switch of binding mode and spectroscopic responses by introducing additional binding sites into the linker.Safety of Ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate hydrochloride.
Two novel guanidiniocarbonyl pyrrole-pyrene conjugates III and IV as spectroscopic probes for ds-polynucleotides were synthesized and their interaction with different ds-DNAs/RNAs studied. Compared to a previously reported first set of conjugates (I and II) the significant extension and increased rigidity of the central part of the structure resulted in a switch of DNA binding mode from intercalative (previously studied derivatives I and II with a nonbinding and flexible linker) to minor groove binding of the two novel guanidiniocarbonyl-pyrrole-pyrene conjugates III and IV. These two compounds interact strongly with ds-DNAs, but only weakly with ds-RNA. The newly incorporated heterocyclic moieties within the central part of the structure of III and IV were able to control by steric and hydrogen-bonding effects the alignment of the mols. within various, structurally different forms of DNA minor grooves, whereby even small differences in the position of the attached pyrene within the groove were reflected in different fluorimetric responses. In addition, III and IV revealed intriguing in vitro selectivity among various human tumor cell lines.
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