Quality Control of (2S)-(+)-3-Chloropropane-1,2-diol. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (2S)-(+)-3-Chloropropane-1,2-diol, is researched, Molecular C3H7ClO2, CAS is 60827-45-4, about A novel method for synthesis of L- and D-glycerol acetonide.
A novel efficient method for preparation. L- and D-glycerol acetonide is described. Highly enantioenriched (S)-epichlorohydrin and (R)-3-chloro-1,2-propanediol were simultaneously prepared by hydrolysis and resolution of racemic epichlorohydrin in presence of a chiral (R,R)-Salen-CoIII complex. (S)-epichlorohydrin was then used to afford L-glycerol acetonide in overall yield of 59.4 % by hydrolysis, condensation with acetone, substitution (acetylation), and alcoholysis. D-glycerol acetonide was prepared from (R)-3-chloro-1,2-propanediol in overall yield of 62.5 %. The chem. structures of the target compounds were confirmed by IR, 1H NMR and MS.
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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com