The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (2S)-(+)-3-Chloropropane-1,2-diol(SMILESS: OC[C@H](O)CCl,cas:60827-45-4) is researched.Reference of 5,5′-Dimethyl-2,2′-bipyridine. The article 《The effect of the isomers of α-chlorohydrin and racemic β-chlorolactate on the rat kidney》 in relation to this compound, is published in Chemico-Biological Interactions. Let’s take a look at the latest research on this compound (cas:60827-45-4).
The (R)- [57090-45-6] and (S)-isomers [60827-45-4] of the male antifertility agent α-chlorohydrin have been synthesized. When administered to rats, the (R)-isomer induced a period of diuresis and glucosuria, whereas the (S)-isomer, which possesses the antifertility activity, had no detrimental action on the kidney. Neither of the isomers of α-chlorohydrin nor those of an active analog, 3-amino-1-chloropropan-2-ol, had any inhibitory activity on the oxidative metabolism of glucose [50-99-7] or lactate [50-21-5] in isolated kidney tubules. However, (RS)-β-chlorolactate [1713-85-5], a metabolite common to both compounds, inhibited the oxidation of glucose, lactate, pyruvate [127-17-3], and glutamate [56-86-0] to CO2. It is proposed that the antifertility action of the (S)-isomers of α-chlorohydrin and 3-amino-1-chloropropan-2-ol is unrelated to the renal toxicity of the (R)-isomers, a toxic action involving the inhibition of oxidative metabolism by (S)-β-chlorolactate or a further product of this metabolite.
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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com