Month: March 2022

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Inhibition of fructolysis in boar spermatozoa by the male antifertility agent (S)-α-chlorohydrin, published in 1982, which mentions a compound: 60827-45-4, Name is (2S)-(+)-3-Chloropropane-1,2-diol, Molecular C3H7ClO2, Name: (2S)-(+)-3-Chloropropane-1,2-diol.

The male antifertility agent (S)-α-chlorohydrin  [60827-45-4] strongly inhibited the oxidative metabolism of fructose  [57-48-7] by boar spermatozoa in vitro. The result of this action, which has been deduced to be an inhibition of glyceraldehyde phosphate dehydrogenase, caused an accumulation of fructose 1,6-bisphosphate  [488-69-7] and the triose phosphates, and a decrease in substrate-level phosphorylation with a concomitant lowering of the energy charge potential of the spermatozoa. (R)-α-chlorohydrin  [57090-45-6] Had no inhibitory activity on fructolysis. A study of the comparative metabolism of (R)-[3-36Cl]-α-chlorohydrin and (R,S)-[3-36Cl]-α-chlorohydrin by boar spermatozoa showed that it is the (S)-isomer that specifically undergoes a process of oxidative metabolism to (R)-3-chlorolactaldehyde  [84607-54-5]. This endogenous oxidation product, which has the same absolute configuration as the substrate for glyceraldehyde phosphate dehydrogenase, may be the active metabolite of (S)-α-chlorohydrin that inhibits this enzyme. Exogenous (R,S)-3-chlorolactaldehyde  [84709-24-0] inhibited the oxidative metabolism of fructose by boar spermatozoa, apparently by a mechanism similar to that of (S)-α-chlorohydrin.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Haakansson, Mikael; Oertendahl, Mikael; Jagner, Susan; Sigalas, Michael P.; Eisenstein, Odile researched the compound: Mesitylcopper(I)( cas:75732-01-3 ).Quality Control of Mesitylcopper(I).They published the article 《Splitting dioxygen with mesitylcopper(I). An arylcopper(I) intermediate, formed in a coupling reaction, containing two trapped trigonal pyramidally coordinated oxides》 about this compound( cas:75732-01-3 ) in Inorganic Chemistry. Keywords: crystal structure hexamesitylene decacopper oxide cluster; mol structure hexamesitylene decacopper oxide cluster; mesitylene copper oxide cluster EHMO. We’ll tell you more about this compound (cas:75732-01-3).

Oxidatively induced reductive coupling of mesityl from mesitylcopper(I) effected by dioxygen is shown to result in an intermediate, [Cu10O2(Mes)6], containing oxide ligands trapped in an unusual coordination mode on the surface of the cluster. [Cu10O2(Mes)6] was characterized by x-ray crystallog. The complex has approx. D3h symmetry such that the two oxide ligands and a central copper(I) are situated on the approx. 3-fold axis while the remaining nine copper(I) centers form three wings, each with three copper(I) atoms participating in 2 electron-3 center bonds with two mesityl groups. Cu···Cu distances involved in the latter interactions range from 2.376(8) to 2.439(6) Å. The oxide ligands are trigonal pyramidally coordinated by four copper(I) atoms at distances of 1.81(2)-1.90(2) Å and are slightly displaced (0.1 Å) from the cluster surface, i.e. from the trigonal coordination plane, toward the central cooper(I). The unusual coordination mode of oxygen on the surface of the cluster, the extreme instability of the complex, and its color are discussed in the context of extended Hueckel (EHT) calculations

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Name: (2S)-(+)-3-Chloropropane-1,2-diol. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (2S)-(+)-3-Chloropropane-1,2-diol, is researched, Molecular C3H7ClO2, CAS is 60827-45-4, about Asymmetric hydrolysis of esters by biochemical methods. Part III. Asymmetric hydrolysis of (±)-1,2-diacetoxy-3-chloropropane and its related compounds with lipase. Synthesis of optically pure (S)-propranolol. Author is Iriuchijima, Shinobu; Kojima, Natsuko.

Asym. hydrolysis of (±)-1,2-diacetoxy-3-chloropropane (I) using lipoprotein lipase gave (S)-I of 90% enantiomeric excess (e.e.). Reactions of (S)-I with phenols in an alk. condition yielded the corresponding (S)-3-aryloxy-1,2-propranediols. (S)-Propranolol was prepared from (S)-3-(1-naphthoxy)-1,2-propanediol. Hydrolysis of (±)-1,2-diacetoxy-3-bromopropane (II) and (±)-1,2-diacetoxyethylbenzene (III) with the lipase afforded (S)-II of 77% e.e. and (R)-III of 73% e.e., resp.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Niemeyer, Mark researched the compound: Mesitylcopper(I)( cas:75732-01-3 ).Safety of Mesitylcopper(I).They published the article 《Reaction of copper aryls with imidazol-2-ylidenes or triphenylphosphine. Formation of 1:1-adducts with two-coordinate copper atoms》 about this compound( cas:75732-01-3 ) in Zeitschrift fuer Anorganische und Allgemeine Chemie. Keywords: imidazolylidene reaction copper aryl; triphenylphosphine reaction copper aryl; copper aryl carbene complex preparation structure DFT; crystal structure copper two coordinate aryl imidazolylidene triphenylphosphine adduct; mol structure copper two coordinate aryl imidazolylidene triphenylphosphine adduct. We’ll tell you more about this compound (cas:75732-01-3).

The reaction of the Cu aryls CuDmp (Dmp = 2,6-Mes2C6H3; Mes = 2,4,6-Me3C6H2) and CuMes with the σ-donors PPh3 and 1,3-diisopropyl-4,5-dimethylimidazol-2-ylidene [C[N(i-Pr)CMe]2] affords the adducts DmpCu←PPh3 (1), DmpCu←C{N(i-Pr)CMe}2 (2) and MesCu←C{N(i-Pr)CMe}2 (3) in 65-84% yields. The colorless compounds were characterized by 1H and 13C NMR spectroscopy, single crystal structure anal., and also by 31P NMR spectroscopy of 1, elemental anal. of 2, mass spectrometry of 2 and 3, IR spectroscopy of 2 and m.p. of 2 and 3. In the solid-state structures the two-coordinate Cu atoms have relatively short Cu-P and Cu-C(carbene) distances of 218.91(11) of 1, 190.2(3) of 2 and 191.1(4) pm of 3. DFT calculations at the B3PW91 level were performed for the model compound PhCu←C[N(H)CH]2 and also for the free carbene ligand C[N(H)CH]2.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Bumagin, N. A.; Kalinovskii, I. O.; Beletskaya, I. P. researched the compound: Mesitylcopper(I)( cas:75732-01-3 ).Safety of Mesitylcopper(I).They published the article 《The palladium-catalyzed cross-coupling reactions of mesitylcopper with aryl iodides》 about this compound( cas:75732-01-3 ) in Journal of Organometallic Chemistry. Keywords: cross coupling reaction mesitylcopper; aryl iodide coupling mesitylcopper; biphenyl. We’ll tell you more about this compound (cas:75732-01-3).

Mesitylcopper reacts with aryl iodides p-IC6H4R (R = MeO, Cl, Ac, CN, NO2), containing both electron-withdrawing and electron-donating groups, in the presence of 1 equiv Bu4NX (X = Br, I) and 1 mol % of PhPdI(PPh3)2 to give cross-coupling products p-R1C6H4R (same R; R1 = mesityl) in high yields.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Activities of various 6-chloro-6-deoxysugars and (S)α-chlorohydrin in producing spermatocoeles in rats and paralysis in mice and in inhibiting glucose metabolism in bull spermatozoa in vitro, published in 1982-05-31, which mentions a compound: 60827-45-4, mainly applied to contraceptive male chlorodeoxy sugar; chlorohydrin male contraceptive; toxicity male contraceptive chlorodeoxysugar, COA of Formula: C3H7ClO2.

6-chloro-6-deoxyglucose (I) [40656-44-8], 6-chloro-6-deoxymannose  [4990-81-2], 6-chloro-6-deoxyfructose  [66451-66-9], 6-chloro-6-deoxyglucitol  [76986-26-0], 6-chloro-6-deoxygalactose  [18465-32-2], and (S)α-chlorohydrin  [60827-45-4] all produced spermatoceles in the efferent ducts and epididymis of the rat and were neurotoxic in the mouse, but only α-chlorohydrin caused substantial inhibition of D-glucose  [50-99-7] metabolism in bull spermatozoa in vitro. The relative potencies of the compounds in producing spermatoceles reflected their activities as reversible antifertility agents in the rat but compared to the others 6-chloro-6-deoxymannose was considerably less neurotoxic to mice than might have been anticipated from its contraceptive dose. Thus, different metabolites may be responsible for causing the antifertility and the neurotoxic effects.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Recommanded Product: 60827-45-4. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (2S)-(+)-3-Chloropropane-1,2-diol, is researched, Molecular C3H7ClO2, CAS is 60827-45-4, about Spontaneous resolution amongst chiral ortho-cyanophenyl glycerol derivatives: an effective preferential crystallization approach to a single enantiomer of the β-adrenoblocker bunitrolol. Author is Bredikhina, Zemfira A.; Akhatova, Flyura S.; Zakharychev, Dmitry V.; Bredikhin, Alexander A..

The β-adrenoblocker bunitrolol I as well as intermediate cyclic sulfate II and glycidyl ether III have been prepared in enantiopure form by starting from enantiopure o-cyanophenyl glycerol ether IV by an entrainment resolution procedure. Thermal investigations reveal that the hydrochloride salt of I forms a moderately stable racemic compound, whereas IV, II and III are conglomerate forming substances potentially capable of entrainment resolution Some chem. and chiroptical characteristics for bunitrolol and possible intermediates in its synthesis were corrected, and configurations were verified with the configuration of hydrochloride salt of I.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

COA of Formula: C7H12ClN3O2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate hydrochloride, is researched, Molecular C7H12ClN3O2, CAS is 180258-46-2, about Guanidiniocarbonyl-pyrrole-aryl conjugates as nucleic acid sensors: switch of binding mode and spectroscopic responses by introducing additional binding sites into the linker.

Two novel guanidiniocarbonyl pyrrole-pyrene conjugates III and IV as spectroscopic probes for ds-polynucleotides were synthesized and their interaction with different ds-DNAs/RNAs studied. Compared to a previously reported first set of conjugates (I and II) the significant extension and increased rigidity of the central part of the structure resulted in a switch of DNA binding mode from intercalative (previously studied derivatives I and II with a nonbinding and flexible linker) to minor groove binding of the two novel guanidiniocarbonyl-pyrrole-pyrene conjugates III and IV. These two compounds interact strongly with ds-DNAs, but only weakly with ds-RNA. The newly incorporated heterocyclic moieties within the central part of the structure of III and IV were able to control by steric and hydrogen-bonding effects the alignment of the mols. within various, structurally different forms of DNA minor grooves, whereby even small differences in the position of the attached pyrene within the groove were reflected in different fluorimetric responses. In addition, III and IV revealed intriguing in vitro selectivity among various human tumor cell lines.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Petukhova, N. I.; Khalimova, L. Kh.; Mitrofanov, D. V.; Gareev, V. M.; Zorin, V. V. researched the compound: (2S)-(+)-3-Chloropropane-1,2-diol( cas:60827-45-4 ).Application In Synthesis of (2S)-(+)-3-Chloropropane-1,2-diol.They published the article 《Rhodococcus sp. 18-19 and Pseudomonas sp. 31-3 as new tools for obtaining of optically active 3-chloro-1,2-propanediol》 about this compound( cas:60827-45-4 ) in Bashkirskii Khimicheskii Zhurnal. Keywords: chloropropanediol kinetic resolution Rhodococcus Pseudomonas. We’ll tell you more about this compound (cas:60827-45-4).

Bacteria synthesizing stereoselective ferments of 3-chloro-1,2-propanediol transformation were isolated from the soil samples. Rhodococcus sp. 18-19 and Pseudomonas sp. 31-3 were revealed to be the most active strains, exhibiting the opposite specificity to diol stereoisomeres. The possibility to use these strains for obtaining of optically active 3-chloro-1,2-propanediol by the kinetic resolution of racemate with help of resting or growing cells was shown. It was found, that (S)-enantiomer (97% ee) can be obtained when using Rhodococcus sp. 18-19 strain, and (R)-enantiomer (96% ee) – when using Pseudomonas sp. 31-3 strain.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

SDS of cas: 75732-01-3. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Mesitylcopper(I), is researched, Molecular C9H11Cu, CAS is 75732-01-3, about Main-Group-Metal and Transition-Metal Complexes Containing Fluorinated β-Diketiminate Ligands. Author is Huse, Kevin; Woelper, Christoph; Schulz, Stephan.

The synthesis of fluorinated β-diketimine LH (1) (L = HC[C(CF3)NC6F5]2) and its reactions with main-group-metal and transition-metal complexes, yielding LAlMe2 (4), LZnEt (5), LCu(C6D6) (6) and LCuCO (7), is reported. 1-7 Were characterized by IR and NMR spectroscopy (1H, 13C, 19F), elemental anal. and single-crystal x-ray diffraction. The C6F5 substituents strongly reduce the π-back-bonding capacity of the β-diketiminate ligand as was shown for 7 by IR spectroscopy.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com