Application of 60827-45-4. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (2S)-(+)-3-Chloropropane-1,2-diol, is researched, Molecular C3H7ClO2, CAS is 60827-45-4, about Study on acute toxicity of R,S and (R,S)-3-chloro-1,2-propanediol.
The aim of the paper was to investigate the acute toxicity of R,S and (R,S)-3-chloro-1,2-propanediol (3-MCPD). Ten, seven and seven groups of sexually mature ICR mice were employed for testing the acute toxicity of R, S and (R,S)-3-MCPD, at the doses of 176.78 mg/kg, 198.43 mg/kg, 222.73 mg/kg, 250 mg/kg, 280.61 mg/kg, 314.98 mg/kg, 353.55 mg/kg, 396.84 mg/kg, 445.44 mg/kg, and 499.99 mg/kg for R-3-MCPD, 89.09 mg/kg, 100 mg/kg, 112.25 mg/kg, 125.99 mg/kg, 141.42 mg/kg, 158.74 mg/kg and 178.18 mg/kg for S-3-MCPD, and 130.25 mg/kg, 150 mg/kg, 172.75 mg/kg, 198.95 mg/kg, 229.13 mg/kg, 263.88 mg/kg and 303.91 mg/kg for (R,S)-3-MCPD, resp. The mice were given three forms of 3-MCPD once by gavage and observed for 14 days, the LD50 was calculated by the modified Karber’s method, and organ/body weight ratios were measured and morphol. changes of liver and kidney were examined Results showed that the LD50 (95% CI) of R, S and (R,S)-3-MCPD was 290.54 mg/kg (280.74-300.68), 117.57 mg/kg (113.82-121.45) and 190.73 mg/kg (177.76-204.59), resp. The kidney/weight ratios in R-3-MCPD treated groups were higher than controls at the doses of 250-353.55 mg/kg (P < 0.05), and the brain weight ratios also had an significant increase in the 353.55 mg/kg, 445.44 mg/kg and above doses (P < 0.05). However, no significant changes on organ/body weight ratio of any organs in S-3-MCPD treated groups were observed The kidney/body weight ratio in (R,S)-3-MCPD treated groups increased significantly at the doses of 198.95-303.91 mg/kg (P < 0.05), and the brain weight ratios also had a significant increase at the doses of 229.13-303.91 mg/kg. At the doses of 353.55-499.99mg/kg, R-3-MCPD caused obvious swell of liver cells and the swell and congestion of the liver sinus. At the dose 229.13 mg/kg and above, (R,S)-3-MCPD also induced the swell of liver cells and congestion of the liver sinus. No obvious morphol. change of kidney after administration of R, S and (R,S)-3-MCPD was observed In conclusion, the acute toxicity of S-3-MCPD might be much higher than those of (R,S)-3-MCPD and R-3-MCPD, and both R-3-MCPD and S-3-MCPD seemed to possess neurotoxicity. There is still a lot of research devoted to this compound(SMILES：OC[C@H](O)CCl)Application of 60827-45-4, and with the development of science, more effects of this compound(60827-45-4) can be discovered.
Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com