In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called A simplified catalytic system for direct catalytic asymmetric aldol reaction of thioamides; application to an enantioselective synthesis of atorvastatin, published in 2011, which mentions a compound: 75732-01-3, mainly applied to atorvastatin enantioselective synthesis; ketoester preparation amination cyclization; hydroxyalkyl thioamide preparation lithium reagent; thioamide aldehyde aldol reaction Cu catalyst, Application of 75732-01-3.
A new catalytic system was developed for the direct catalytic asym. aldol reaction of thioamides. The new lithium-free Cu catalyst (second-generation catalyst) exhibited enhanced catalytic efficiency over the previously developed catalyst comprising [Cu(CH3CN)4]PF6/Ph-BPE/LiOAr (first-generation catalyst), which required a tedious catalyst preparation process. In the reaction with the second-generation catalyst, the intermediate Cu-aldolate functioned as a Bronsted base to generate thioamide enolate, efficiently driving the catalytic cycle. The present aldol methodol. culminated in a concise asym. synthesis of atorvastatin I (Lipitor: atorvastatin calcium), a widely prescribed HMG-CoA reductase inhibitor for lowering low-d. lipoprotein cholesterol.
There is still a lot of research devoted to this compound(SMILES：[Cu]C1=C(C)C=C(C)C=C1C)Application of 75732-01-3, and with the development of science, more effects of this compound(75732-01-3) can be discovered.
Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com