Synthetic Route of C7H12ClN3O2. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate hydrochloride, is researched, Molecular C7H12ClN3O2, CAS is 180258-46-2, about In vivo imaging of pyrrole-imidazole polyamides with positron emission tomography. Author is Harki, Daniel A.; Satyamurthy, Nagichettiar; Stout, David B.; Phelps, Michael E.; Dervan, Peter B..
The biodistribution profiles in mice of two pyrrole-imidazole polyamides were determined by PET. Pyrrole-imidazole polyamides are a class of small mols. that can be programmed to bind a broad repertoire of DNA sequences, disrupt transcription factor-DNA interfaces, and modulate gene expression pathways in cell culture experiments The 18F-radiolabeled polyamides were prepared by oxime ligation between 4-[18F]-fluorobenzaldehyde and a hydroxylamine moiety at the polyamide C terminus. Small animal PET imaging of radiolabeled polyamides administered to mice revealed distinct differences in the biodistribution of a 5-ring β-linked polyamide vs. an 8-ring hairpin, which exhibited better overall bioavailability. In vivo imaging of pyrrole-imidazole polyamides by PET is a min. first step toward the translation of polyamide-based gene regulation from cell culture to small animal studies.
There is still a lot of research devoted to this compound(SMILES：O=C(C1=NC(N)=CN1C)OCC.[H]Cl)Synthetic Route of C7H12ClN3O2, and with the development of science, more effects of this compound(180258-46-2) can be discovered.
Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com