Jones, A. R.; Ford, S. A. published the article 《The action of (S)-α-chlorohydrin and 6-chloro-6-deoxyglucose on the metabolism of guinea pig spermatozoa》. Keywords: chlorohydrin sperm metabolism; chlorodeoxyglucose sperm metabolism; glycolysis sperm chlorohydrin chlorodeoxyglucose; lactate fructose sperm chlorohydrin chlorodeoxyglucose; fructose lactate sperm chlorohydrin chlorodeoxyglucose.They researched the compound: (2S)-(+)-3-Chloropropane-1,2-diol( cas:60827-45-4 ).Recommanded Product: 60827-45-4. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:60827-45-4) here.
(S)-α-Chlorohydrin [60827-45-4] inhibited the conversion of D-fructose [57-48-7] to lactate [50-21-5] by mature guinea pig spermatozoa in vitro. At 2 mM, there was a specific inhibition of glyceraldehyde-phosphate dehydrogenase [9001-50-7], resulting in the accumulation of fructose 1,6-bisphosphate [488-69-7], dihydroxyacetone 3-phosphate [57-04-5], and glyceraldehyde 3-phosphate [591-59-3] and a concomitant decrease in the concentration of endogenous lactate. (R,S)-[3-36Cl]-α-chlorohydrin was metabolized by the spermatozoa to 3-chlorolactaldehyde [84709-24-0] of unknown configuration. Exogenous (R,S)-3-chlorolactaldehyde [84709-24-0] (2 mM) was an inhibitor of glyceraldehyde-phosphate dehydrogenase in guinea pig spermatozoa, whereas (R)-α-chlorohydrin [57090-45-6] (10 mM) had no significant effect on the metabolism of fructose. 6-Chloro-6-deoxyglucose [40656-44-8] (10 mM) inhibited glyceraldehyde-phosphate dehydrogenase in guinea pig spermatozoa in vitro and was metabolized to 3-chlorolactaldehyde which was presumably the (S)-isomer. The antiglycolytic actions of (S)-α-chlorohydrin and 6-chloro-6-deoxyglucose in guinea pig spermatozoa are probably due to the action of a common metabolite, (S)-3-chlorolactaldehyde [86747-03-7].
There is still a lot of research devoted to this compound(SMILES：OC[C@H](O)CCl)Recommanded Product: 60827-45-4, and with the development of science, more effects of this compound(60827-45-4) can be discovered.
Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com