Month: September 2021

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 618-91-7, name is Methyl 3-iodobenzoate belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C8H7IO2

General procedure: To a mixture of Iodobenzene (1.0 mmol), styrene (1.2 mmol), NaOAc (1.5 mmol), Catalyst (0.007 mmol) and DMF (3mL) was added in round bottom flask. (No inert gas protection was needed.). The reaction was carried out at 120 C for 15 min. Upon completion of reaction as indicated by TLC, the reaction mixture was poured in crushed ice-water, extracted with ethyl acetate, dried over anhydrous Na2SO4, concentrated in vacuum to give crude product which was purified through column chromatography on silica gel (100-200) to afforded pure stilbenes in 90-98% yields.

The synthetic route of 618-91-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Sharma, Sonam; Sarkar, Bibhas R.; Synthetic Communications; vol. 48; 8; (2018); p. 906 – 914;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Some common heterocyclic compound, 108078-14-4, name is 2-Iodo-3-methylbenzoic acid, molecular formula is C8H7IO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 108078-14-4

General procedure: A mixture of 2-iodobenzoic 1a (0.2 mmol), acetylacetone 2a (0.4 mmol), and Cs2CO3 (65.2 mg, 0.20 mmol) in CH3CN was stirred at 100 C. When the reaction was considered complete as determined by TLC analysis, the reaction was allowed to cool to room temperature and quenched by water, and the mixture was extracted with CH2Cl2. The combined organic extracts were washed with water and saturated brine. The organic layers were dried over Na2SO4, filtered. Solvents were evaporated under reduced pressure. The residue was purified by chromatography on silica gel to afford isocoumarins derivatives and isoquinolone derivatives.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 108078-14-4, its application will become more common.

Reference:
Article; Liu, Lei; Hu, Jie; Wang, Xiang-Chuan; Zhong, Mei-Jin; Liu, Xue-Yuan; Yang, Shang-Dong; Liang, Yong-Min; Tetrahedron; vol. 68; 27-28; (2012); p. 5391 – 5395;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 58755-70-7, The chemical industry reduces the impact on the environment during synthesis 58755-70-7, name is 1-Iodo-4-methoxy-2-nitrobenzene, I believe this compound will play a more active role in future production and life.

Method A applied to 1-lodo-4-methoxy-2-nitrobenzene (140 mg, 0.5 mmol) and pyrrolidin-2-one (51 mg, 0.6 mmol) afforded the title compound as a viscous oil (84 mg, 89%). 1H NMR (DMSO) delta 2.74 (t, J = 6.9 Hz, 2 H), 3.24-3.32 (m, 2 H), 3.86 (s, 3 H),0 4.32 (t, J = 7.1 Hz, 2 H), 7.09 (d, J = 9.1 Hz, 1 H), 7.44 (d, J = 9.1 Hz, 1 H), 7.58 (s, 1 H); 13C NMR delta 23.6, 25.3, 45.4, 55.9, 96.0, 114.6, 115.6, 128.7, 129.6, 157.4, 158.2.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Iodo-4-methoxy-2-nitrobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SANOFI AVENTIS; WO2009/412; (2008); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 2265-91-0,Some common heterocyclic compound, 2265-91-0, name is 1,3-Difluoro-5-iodobenzene, molecular formula is C6H3F2I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: (S)-3-((R)-Hydroxyphenylmethyl)pyrrolidine-1-carboxylic acid t-butyl ester 11a (250 mg, 0.9 mmol), copper(I) iodide (51 mg, 270 mumol), 1,10-phenanthroline (97 mg, 540 mumol) and 2,4-difluoro-1-iodobenzene (216 muL, 1.8 mmol) were combined in a vial under air. Toluene (1.4 mL, 14 mmol) was added, followed by the addition of cesium carbonate (587 mg, 1.8 mmol). Air was bubbled through the mixture, the vial was sealed, and the mixture was heated at 105C for 48 hours. The mixture was filtered through Celite. The Celite was then rinsed with DCM (2 x 15 ml), and the resultant filtrate was concentrated. The resultant oil was treated with 1.25 M of HCl in EtOH (5.8 mL, 7.2 mmol) and stirred overnight. The mixture was concentrated and purified by reverse phase preparative HPLC (10 to 70% CH3CN in water with 0.5% TFA) to yield 76 mg (97% purity, 26% yield) of the title compound as the mono-TFA salt.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,3-Difluoro-5-iodobenzene, its application will become more common.

Reference:
Article; Van Orden, Lori Jean; Van Dyke, Priscilla M.; Saito, D. Roland; Church, Timothy J.; Chang, Ray; Smith, Jacqueline A.M.; Martin, William J.; Jaw-Tsai, Sarah; Stangeland, Eric L.; Bioorganic and Medicinal Chemistry Letters; vol. 23; 5; (2013); p. 1456 – 1461;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 26059-40-5, The chemical industry reduces the impact on the environment during synthesis 26059-40-5, name is 2-(2-Iodophenyl)ethan-1-ol, I believe this compound will play a more active role in future production and life.

Aryl iodide 9 (1.15 g, 4.63 mmol) and stannane 183 (2.08 g, 6.98 mmol) were dissolved in toluene (15 mL) under argon. The solution was degassed for 10 minutes. Pd2(dba)3 (430 mg, 0.47 mmol) was added at room temperature, followed by P(t-Bu)3 (112 mg, 0.55 mmol, 10% in hexane). The reaction was heated at 80 C and stirred for 12 hours at that temperature. After cooling at room temperature, the solution was filtered through a silica plug and concentrated under reduced pressure. Silica gel flash chromatography provided alcohol 19 as oil (963 mg, 68%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(2-Iodophenyl)ethan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Fischer, Derek; Nguyen, Thong X.; Trzoss, Lynnie; Dakanali, Marianna; Theodorakis, Emmanuel A.; Tetrahedron Letters; vol. 52; 38; (2011); p. 4920 – 4923;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 328-73-4,Some common heterocyclic compound, 328-73-4, name is 1-Iodo-3,5-bis(trifluoromethyl)benzene, molecular formula is C8H3F6I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

N-Methyl-2-pyrrolidone (10 mL) was added to 4-bromothiophenol (0.500 g, 2.64 mmol) in a sealed tube and the mixture was purged with argon for 5 minutes. After this time, 3,5-bis(trifluoromethyl)iodobenzene (0.89 g, 2.64 mmol), CuCl (0.131 g, 1.32 mmol), tetramethyl heptanedione (0.14 mL, 0.66 mmol) and cesium carbonate (1.70 g, 5.28 mmol) were added to the reaction mixture. The reaction mixture was stirred at 130° C. under argon for 2 hours. The reaction mixture was cooled to room temperature, diluted with ethyl acetate, and filtered through a celite bed. The filtrate was washed with water and brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to yield the crude product. Silica gel chromatography (neat hexanes) provided impure 1-(4-bromo-phenylsulfanyl)-3,5-bis(trifluoromethyl)benzene (0.44 g). MS calcd. for C14H8BrF6S [(M+H)+] 402, obsd. 402.

The synthetic route of 328-73-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hoffmann-La Roche Inc.; Firooznia, Fariborz; Lin, Tai-An; Mertz, Eric; So, Sung-Sau; Sidduri, Achyutharao; Tilley, Jefferson Wright; US2013/225588; (2013); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 32024-15-0, name is 3-Iodo-4,5-dimethoxybenzaldehyde, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 32024-15-0, COA of Formula: C9H9IO3

To a mixture of N-(tert-butyl)hydroxylamine hydrochloride (S3) (930 mg, 7.44 mmol), 3-iodo-4,5-dimethoxybenzaldehyde (S4) (3.27 g, 11.2 mmol, 1.50 equiv), triethylamine (2.06 mL, 14.9 mmol, 2.00 equiv), and MgSO4 (4.46 g, 37.2 mmol, 5.00 equiv) were added toluene (100 mL) at room temperature and the mixture was refluxed with stirring for 3 days. After cooling to room temperature, to the mixture was added water (50 mL) and the mixture was extracted with EtOAc (50 mL × 3). The combined organic extract was washed with aqueous saturated solution of sodium bicarbonate (20 mL), brine (20 mL), dried (Na2SO4),and after filtration, the filtrate was concentrated under reduced pressure. The residue was purified by flash column chromatography (silica-gel 70.0 g, n-hexane/EtOAc = 10/1) to give N-tert-butyl(3-iodo-4,5-dimethoxybenzylidene)amine N-oxide (9) (1.69 g, 4.66 mmol, 62.6%) as a colorless solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Iodo-4,5-dimethoxybenzaldehyde, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Yoshida, Suguru; Uchida, Keisuke; Hosoya, Takamitsu; Chemistry Letters; vol. 44; 5; (2015); p. 691 – 693;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 135050-44-1, name is 3-Chloro-4-iodoaniline, A new synthetic method of this compound is introduced below., category: iodides-buliding-blocks

Ethyl 3-(5-(2-(bromomethyl)-4,5-difluorophenyl)picolinamido)propanoate (1.0 g, 2.3 mmol), 3-chloro-4-iodoaniline (1.2 g, 4.7 mmol), and K2CO3 (647 mg, 4.7 mmol) were diluted with DMF (2.4 mL) and the resulting mixture was stirred at room temperature. After 2 h the resulting mixture directly purified via column chromatography to yield the title compound.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Chakravarty, Devraj; Kreutter, Kevin; Powell, Mark; Shook, Brian; Song, Fengbin; Xu, Guozhang; Yang, Shyh-Ming; Zhang, Rui; Zhao, Bao-Ping; US2012/302610; (2012); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 460-37-7, name is 1,1,1-Trifluoro-3-iodopropane, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C3H4F3I

[0265] A solution of Mg (1.16 g, 1.6 eq.) and I2 (cat.) in Et2O (48 mL) was treated with 3,3,3-trifluoro-1-iodopropane (8.0 g, 1.2 eq. initially 20% of total) and the resulting solution was heated to reflux to initiate Grignard formation. Following initiation, the remaining 3,3,3-trifluoro-1-iodopropane was added dropwise to maintain a gentle reflux. The reaction mixture was stirred at room temperature an additional hour and transferred via canulae to a solution of 4-trifluorobenzaldehyde (4.1 mL, 30 mmol) in Et2O (95 mL) at 0 C. The resulting solution was stirred at 0 C. for 1 hour and room temperature for 1 hour. The reaction was quenched by pouring it over ice (100 g) and saturated NH4Cl. The resulting solution was extracted with CH2Cl2, the combined organics were dried over Na2SO4, filtered, concentrated and used without further purification.

According to the analysis of related databases, 460-37-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Schering Corporation; US2003/232837; (2003); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

460-37-7, name is 1,1,1-Trifluoro-3-iodopropane, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C3H4F3I

110 g (760 mmol) of thiobarbituric acid of formula (XI) was added to 360 mL of water at room temperature,System was suspended state,66.9 g (1.67 mol) of sodium hydroxide was added to the system,The system gradually become clear,Plus,Stir at room temperature for 0.5 h.To the system was added 220 ml of N, N-dimethylformamide,Then 340.4 g (1.52 mol) of 1-iodo-3,3,3-trifluoropropane was added to the system,Plus,Heating to 60 C stirring reaction 8h,TLC monitoring to the basic disappearance of raw materials,The reaction is complete,Stop the reaction,Cooling to room temperature,With 2mol / L hydrochloric acid to adjust the pH to 2.5,filter,Washed cake,After solid drying,Beating,Filtered to give 171.5 g of a white solid,I.e. a compound of formula (X)Yield: 94%

The synthetic route of 460-37-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shandong Bainuo Pharmaceutical Co., Ltd.; Zhen Yizhan; Zhang Zhiqiang; Gao Changsong; Lv Wei; Zhang Zhen; (19 pag.)CN105061431; (2017); B;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com