Application of 112671-42-8,Some common heterocyclic compound, 112671-42-8, name is 4-Bromo-1-iodo-2-nitrobenzene, molecular formula is C6H3BrINO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The starting material, phenylboronic acid (76.84g, 630.2mmol) was dissolved in a THF(2780ml) in a round bottom flask, 4-bromo-1-iodo-2-nitrobenzene (309.96g,945.3mmol), Pd (PPh3) 4 ( was added 36.41g, 31.5mmol), K2CO3 (261.3g,1890.6mmol), water (1390ml) and the resulting mixture was stirred at 80 C. After the reaction was completed CH2Cl2 and water, the organic layer was dried overMgSO4, and extracted with silicagel column and re-crystallization and the resultingcompound and then concentrated to give 122.68g product (yield: 70%) was obtained.
The synthetic route of 112671-42-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Duksan Neolux Co. Ltd.; Moon, Song Yun; Lee, Son Hui; Park, Jong Cheol; Kim, Dae Song; Lee, Bom Song; Kim, Seok Hyeon; (113 pag.)KR2015/98171; (2015); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com