Synthetic Route of 328-73-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 328-73-4 as follows.
General procedure: In a round-bottomed flask filled with 50 mL of water, prop-2-ynyl-2-azidobenzoates (2a?b, 1.0 equiv), aryl halides (3a?j, 1.5 equiv), Pd(CH3CN)2Cl2 (2.5 mol percent), ligand 1b (5 mol percent) and iPr2EtN (3.0 equiv) were stirred vigorously under sonication at 80 °C for 30?40 min under atmospheric condition in the presence of CTAB (4 mmol). When TLC indicated completion of the reaction, the mixture was extracted with ethyl acetate (3 × 25 mL) and washed thoroughly with water. Column chromatography [silica gel (60?120), petroleum ether?ethyl acetate (5:1) as eluent] produced pure products (4a?j)
According to the analysis of related databases, 328-73-4, the application of this compound in the production field has become more and more popular.
Reference:
Article; Pal, Rammyani; Sarkar, Swarbhanu; Chatterjee, Nivedita; Sen, Asish Kumar; Tetrahedron Letters; vol. 55; 8; (2014); p. 1452 – 1455;,
Iodide – Wikipedia,
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