Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 63262-06-6, name is 1,4-Dibromo-2,5-diiodobenzene, A new synthetic method of this compound is introduced below., Product Details of 63262-06-6
According to the above reaction formula, under nitrogen protection, the purchased 1,4-dibromo-2,5-diiodobenzene (1.00g/2.05mmol),Carbazole (514.29mg, 3.08mmol), potassium hydroxide (230.1mg, 4.10mmol 2,2,6,6-Tetramethyl-3,5-heptanedione (37.80mg, 0.205mmol) and cuprous oxide (29mg, 0.205mmol) were added to 10mL DMF,After heating to 110C for 124 hours, the reaction was extracted three times with 50 ml of saturated brine and 15 ml of dichloromethane.The organic phase was dried over anhydrous sodium sulfate, filtered and concentrated. The crude product was purified by column chromatography using petroleum etherdichloromethane=3:1 (VV) as eluent.1.02 g of white solid product was obtained with a yield of 87.8%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; South China University of Technology; Ying Lei; Zhong Zhiming; Li Yuanfeng; Guo Ting; Peng Junbiao; Cao Yong; (11 pag.)CN111116455; (2020); A;,
Iodide – Wikipedia,
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