Synthetic Route of 791642-68-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 791642-68-7, name is 4-Bromo-1-iodo-2-methoxybenzene, This compound has unique chemical properties. The synthetic route is as follows.
A mixture of 4-bromo-1-iodo-2-methoxybenzene (4Og, 128mmol), 4-methylimidazole (10.5g, 128mmol), CuI (2.44g, 12.8mmol), 8-hydroxyquinoline (1.84g, 12.8mmol), Cs2CO3 (125g, 384mmol) in DMF (400ml) was heated to 7O0C overnight. The reaction was quenched by the addition of water. The mixture was extracted with EtOAc. The combined organic layers were washed with water, dried over anhydrous Na2SO4, and concentrated. Purification via the CombiFlash system (PE/EtOAc 5:1 ) then afforded the title compound as a colorless oil (16g, 47%): LC-MS m/z 268 (M+H)+, 1.57 min (ret time).
The chemical industry reduces the impact on the environment during synthesis 4-Bromo-1-iodo-2-methoxybenzene. I believe this compound will play a more active role in future production and life.
Reference:
Patent; GLAXO GROUP LIMITED; WO2009/50227; (2009); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com