Some common heterocyclic compound, 159217-89-7, name is tert-Butyl (4-iodophenyl)carbamate, molecular formula is C11H14INO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C11H14INO2
fert-Butyl 4-iodophenylcarbamate (prepared using the method described in Bioorganic and Med. Chem. Lett, 2000, 8, 1203; 1.77 g, 5.55 mmol) and trans-dichlorobis (triphenylphosphine) palladium (II) (195 mg, 0.28 mmol) were weighed into a flask. The flask was degassed and placed under argon, and 1,4-dioxane (30 ml) was added. The hexamethylditin (2.00 g, 6.10 mmol) was dissolved in 5 ml of 1 ,4-dioxane, and the solution was added to the mixture. The suspension was heated at 90 C for ca. 16 h. The mixture was adsorbed onto silica gel and concentrated under vacuum. The material was purified by flash chromatography on silica gel using 1% EtOAc/hexanes to give 860 mg of the desired product. NMR: 0.23 (s, 9H), 1.47 (s, 9H), 7.33 (d, 2H), 7.42 (d, 2H), 9.28 (s, IH).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 159217-89-7, its application will become more common.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/92599; (2006); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com