Electric Literature of 877264-43-2, A common heterocyclic compound, 877264-43-2, name is (5-Fluoro-2-iodophenyl)methanol, molecular formula is C7H6FIO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 1 : Compound 10 (1.89 g, 7.5 mmol), compound 29 (2.28 g, 9 mmol), and cesium carbonate (6.1 1 g, 18.7 mmol) were combined in acetonitrile (75 mL), and heated at 80C for 18 hours. The crude suspension was added to brine (400 mL) and the resulting rust colored solids were collected by filtration and rinsed with water. The partially dried solids were recrystallized from hot acetonitrile (-200 mL) to afford compound 436 (2.37 g, 75%) as an orange solid. 1H NMR (400 MHz, DMSO-d6) delta 7.92 (dd, 1 H), 7.58 – 7.69 (m, 2 H), 7.05 (td, J = 8.65, 3.24 Hz, 1 H), 6.69 (s, 2 H), 5.27 (s, 2 H). LCMS m/z 423/425 [M+H]+.
The synthetic route of 877264-43-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PFIZER INC.; BAILEY, Simon; BURKE, Benjamin, Joseph; COLLINS, Michael, Raymond; CUI, Jingrong, Jean; DEAL, Judith, Gail; HOFFMAN, Robert, Louis; HUANG, Qinhua; JOHNSON, Ted, William; KANIA, Robert, Steven; KATH, John, Charles; LE, Phuong, Thi, Quy; MCTIGUE, Michele, Ann; PALMER, Cynthia, Louise; RICHARDSON, Paul, Francis; SACH, Neal, William; WO2013/132376; (2013); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com