These common heterocyclic compound, 19094-56-5, name is 2-Chloro-5-iodobenzoic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 2-Chloro-5-iodobenzoic acid
Analogous to the preparation of 4a, 2-chloro-5-iodobenzoic acid (2.81g, 10mmol) was treated with thionyl chloride (7 mL)
The synthetic route of 2-Chloro-5-iodobenzoic acid has been constantly updated, and we look forward to future research findings.
Reference:
Article; Zhi, Ying; Gao, Li-Xin; Jin, Yi; Tang, Chun-Lan; Li, Jing-Ya; Li, Jia; Long, Ya-Qiu; Bioorganic and Medicinal Chemistry; vol. 22; 14; (2014); p. 3670 – 3683;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com