These common heterocyclic compound, 83171-49-7, name is 3-Chloro-5-iodoaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 83171-49-7
EXAMPLE 25 Trans-2-carboxy-7-chloro-5-iodo-4-methoxycarbonyl-1,2,3,4-tetrahydroquinoline This compound was prepared by the route outlined in Example 15 and 16 using 3-chloro-5-iodoaniline as starting material (colourless foam); delta (360 MHz, CDCl3), 1.95 (1H, ddd, J=14.4, 12.2 and 5.6 Hz, CHA CHB HC CHD), 2.72 (1H, dm, J=14.4 Hz, CHA CHB HC CHD), 3.76 (3H, s, CH3), 3.98 (1H, dd, J=5.6 and 2.1 Hz, CHA CHB HC CHD), 4.09 (1H, dd, J=12.2 and 3.4 Hz, CHA CHB HC CHD), 6.64 (1H, d, J=1.9 Hz, 6-H or 8-H), 7.20 (1H, d, J=1.9 Hz, 6-H and 8-H); m/e 395 (M+), 290 (100%, M-H, CO2 H, CO2 Me); Found: C, 36.88; H, 3.00; N, 3.38. C12 H11 C1INO4 requires C, 36.44; H, 2.80; N, 3.54%.
The synthetic route of 3-Chloro-5-iodoaniline has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Merck Sharp & Dohme, Ltd.; US5231102; (1993); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com