Electric Literature of 5876-51-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5876-51-7, name is 5-Iodobenzo[d][1,3]dioxole, This compound has unique chemical properties. The synthetic route is as follows.
5.5 Example 5: Synthesis of Compound 1009 (c); Compound 1009 (c) was prepared according to the following scheme. A mixture of Compound 40 (Aldrich Chemical, 2.3 g, 32 mmol), Compound 41 (Aldrich Chemical, 5 g, 26 mmol), HOBT (4 g, 30 mmol), and DCM (200 mL) under argon in a 500 mL-flask was cooled with water and to the mixture was added DIC (4 g, 33 mmol) over about 1 hour. The resulting mixture was stirred at about 25C for about 10 hours. The resultant, filtered solid was removed through filtration and the filtrate was washed with water (100 mL) and aqueous 2N NaOH (40 mL). The organic layer was collected and concentrated under reduced pressure to provide crude Compound 42 (6 g) as brown solid. A mixture of crude Compound 42 (1.5 g, 6 mmol), Compound 43 (available from Oakwood Products Inc., West Columbia, SC; 2 g, 8 mmol), EtOAc (100 mL), TEA (2 mL), (Ph3P) 2PdCl2 (0.2 g, 0.25 mmol), and Cul (200 mg, 1 mmol) in a 250 mL-flask was flushed with argon three times. The reaction mixture was heated to about 50C under argon for about 6 hours. The reaction mixture was concentrated and purified using flash chromatography on a silica gel column of the type described previously in Example 1 eluting with a mixed solvent of 3: 7 EtOAc: hexane to provide 2 g of Compound 44 as a yellow solid (83% yield). The structure of Compound 44 was confirmed by 1H NMR. Compound44 : lHNMR (CDCl3) : o (ppm): 7.11 (dd, J = 1. 5,8. 1Hz, 1H), 6.97 (d, J = 1. 3Hz, 1H), 6.8 (d, J = 8. 1Hz =, 1H), 6.02 (s, 2H), 3.76-3. 79 (m, 2H), 3.64-3. 67 (m, 2H), 3.51-3. 53 (m, 2H), 3.44-3. 46 (m, 2H), 1.47 (s, 9H).
The chemical industry reduces the impact on the environment during synthesis 5-Iodobenzo[d][1,3]dioxole. I believe this compound will play a more active role in future production and life.
Reference:
Patent; EURO-CELTIQUE S.A.; WO2005/56524; (2005); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com