Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 455-13-0, name is 4-Iodobenzotrifluoride, A new synthetic method of this compound is introduced below., Quality Control of 4-Iodobenzotrifluoride
General procedure: A sealed 10 mL glass tube containing aryl halide (1 mmol), CS2(0.5 mmol) and [DBUH]+[OAc]- (1 mL) was placed in the cavity of a microwave reactor and irradiated for 5-60 min at 100-120 C and power 150 W. After cooling to room temperature, the reaction mixture was extracted with Et2O (3 × 5 mL) and the [DBUH]+[OAc]-was separated from the product. The organic layers were combined and the solvent removed under reduced pressure to provide the crude product, which was further purified by column chromatography on silica gel using petroleum ether/EtOAc as the eluent. The recovered [DBUH]+[OAc]- was washed with diethyl ether and could be reused in the next reaction. All of the products are known compounds and their characterisation data were compared and are consistent with literature reports.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Zhou, Yongsheng; Journal of Chemical Research; vol. 40; 5; (2016); p. 305 – 307;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com