Application of 354574-31-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 354574-31-5, name is 2-Iodo-6-methoxyaniline belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
A mixture of 2-iodo-6-methoxybenzenamine 10 (2.49 g, 10 mmol), methyl5-formylpentanoate 11 (1.59 g, 11 mmol) and DABCO (6.60 g, 30 mmol) in dry DMF (45 mL) was degassed for 20 min. Pd(OAc)2 (230 mg, 1 mmol) was added to the reaction,and the resulting mixture was heated at 85C under argon atmosphere overnight. The reaction mixture was cooled to room temperature and diluted with water followed by extraction with EtOAc.The combined organic layers were washed with brine, dried over Na2SO4, filtered and concentratedin vacuo. The residue was purified by FCC (PE-Acetone, 8:1) to give 12 (1.43 g, 58%) as white foam.
The synthetic route of 2-Iodo-6-methoxyaniline has been constantly updated, and we look forward to future research findings.
Reference:
Article; Wang, Bin; Qin, Hua; Zhang, Fengying; Jia, Yanxing; Tetrahedron Letters; vol. 55; 9; (2014); p. 1561 – 1563;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com