Adding a certain compound to certain chemical reactions, such as: 90347-66-3, name is Methyl 3-iodo-4-methylbenzoate, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 90347-66-3, Product Details of 90347-66-3
A mixture of methyl 3-iodo-4-methylbenzoate (2 g, 7.2 mmol, 1.0 eq) and CuCN (774 mg, 8.6 mmol, 1.2 eq) in NMP (20 mL) was stirred at 200 C wiht microwave for 1 h. Then the mixture was poured into water (50 mL), extracted with EtOAc (50 mL x3). The combined organic layers were washed with brine (20 mL), dried over anhydrous Na2S04 and concentrated. The residue was purified on silica gel column (PE/EtOAc = 5/1) to afford methyl 3-cyano-4-methylbenzoate as a white solid (1.2 g, 95%>).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 3-iodo-4-methylbenzoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; LIFESCI PHARMACEUTICALS, INC.; MCDONALD, Andrew; WO2015/103317; (2015); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com