In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 624-75-9 as follows. Recommanded Product: 624-75-9
General procedure: A 1.5 mL (1.5 mmol) ofPhBCl2 (1.0 mol/L in CH2Cl2) was added to CH2Cl2 solution(4 mL) of the nitrile (5a) (173 mg, 1.2 mmol) at room temperatureunder argon. The mixture was stirred for 15 min. Theindole (1a) (131 mg, 1.0 mmol) was added dropwise to this solutionat room temperature. The resulting solution was stirredfor 3 h, and then 0.5 mol/L Na2CO3 was added to quench thereaction. The resulting mixture was extracted with CH2Cl2.The organic layer was washed with saturated brine, dried(MgSO4), and evaporated. The crude product was purifiedusing silica gel chromatography to provide 3aa (226 mg, 82%yield).
According to the analysis of related databases, 624-75-9, the application of this compound in the production field has become more and more popular.
Reference:
Article; Mizoi, Kenta; Mashima, Yu; Kawashima, Yuya; Takahashi, Masato; Mimori, Seisuke; Hosokawa, Masakiyo; Murakami, Yasuoki; Hamana, Hiroshi; Chemical and Pharmaceutical Bulletin; vol. 63; 7; (2015); p. 538 – 545;,
Iodide – Wikipedia,
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