Related Products of 214279-40-0, A common heterocyclic compound, 214279-40-0, name is 2-Iodo-4-methoxy-1-nitrobenzene, molecular formula is C7H6INO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The title compound was prepared with the analogous procedure described in example 1 using 2-lodo-4-methoxy-1 -nitrobenzene (140 mg, 0.5 mmol) and lambda/-Phenyl- formamide (73 mg, 0.6 mmol) as starting materials to yield the title compound as viscous oil (62 mg, 56%). 1H NMR (DMSO) delta 2.58 (s, 3 H), 2.64 (s, 3 H), 7.37 (d, J = 8.1 Hz, 1 H), 7.44 (dd, J = 8.1 , 7.3 Hz, 1 H), 7.48-7.52 (m, 1 H), 7.54 (d, J = 8.8 Hz, 2 H), 7.61 (d, J = 8.8 Hz, 2 H), 7.86 (d, J = 7.3 Hz, 1 H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; SANOFI-AVENTIS; WO2009/413; (2008); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com