Application of 148836-41-3, These common heterocyclic compound, 148836-41-3, name is 1-Bromo-4-chloro-2-iodobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Synthesis of Intermediate 1-6-1: 165 ml of dioxane solvent was added to a three-necked flask.5 ml of water, followed by 0.1 mol of 3-boronic acid benzofuran,0.1 mol of 1-bromo-3-chloro-2-iodobenzene,0.25 mol of potassium carbonate,0.001 mol of ferrocene palladium dichloride,Stir the mixture to reflux,After 4 hours, the reaction of the raw materials was completed, and the reaction solution was dried under reduced pressure.Intermediate 1-6-1 was obtained by column chromatography(Yield 71%).
The synthetic route of 148836-41-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Beijing Lv Ren Science And Technology Co., Ltd.; Lv Yao; Feng Meijuan; (40 pag.)CN109206431; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com