Related Products of 391211-97-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 391211-97-5 as follows.
A dry 100 mL round bottomed flask was charged with a mixture of the substituted benzoic acid, and 5 mL of DCM. The reaction mixture was cooled with an ice-bath to 0 oC. A 100 muL volume of anhydrous DMF was added followed by dropwise addition of neat oxalyl chloride (2 equiv.) over 5 min. The reaction was stirred at 23 oC for 4 h. The solvent was removed under reduced pressure. Excess oxalyl chloride was azeotropically removed with 2 X 5 mL portions of DCM under reduced pressure. The crude acid chloride was dissolved into 5 mL of DCM and a greater than 2-fold stoichiometric ratio the appropriate amine was added neat at 0 oC. The ice bath was removed after 10 min and the reaction was permitted to warm to room temperature. The reaction was then stirred at 23 oC for 6 h; completion of reaction was determined by TLC. A mixture of 10 mL of H2O and 10 mL of Et2O was added and the resultant mixture was extracted with twice with 10 mL portions of Et2O, washed twice with 10 mL portions of NaCl (aq, sat), and dried over Na2SO4. The extract was decanted and then the solvent was removed under reduced pressure. The crude product was isolated on SiO2 using hexane/EA.
According to the analysis of related databases, 391211-97-5, the application of this compound in the production field has become more and more popular.
Reference:
Article; Chakrabarty, Suravi; Monlish, Darlene A.; Gupta, Mohit; Wright, Thomas D.; Hoang, Van T.; Fedak, Mitchel; Chopra, Ishveen; Flaherty, Patrick T.; Madura, Jeffry; Mannepelli, Shankar; Burow, Matthew E.; Cavanaugh, Jane E.; Bioorganic and Medicinal Chemistry Letters; vol. 28; 13; (2018); p. 2294 – 2301;,
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