Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 112671-42-8, name is 4-Bromo-1-iodo-2-nitrobenzene, This compound has unique chemical properties. The synthetic route is as follows., Safety of 4-Bromo-1-iodo-2-nitrobenzene
Intermediate M2-b (4.8 g, 15 mmol),2-Iodo-5-bromonitrobenzene (5.9 g, 18 mmol), sodium tert-butoxide(2.9g, 30mmol), toluene 50mL, nitrogen protection,0.17 g of Pd2(dba)3, tri-tert-butylphosphine(11ml, 10% toluene solution), stirring turned on,Heated to 100 C reflux, reaction 12h, the reaction solution washed,The organic phase was concentrated and passed through a silica gel column. The eluent was petroleum ether:Ethyl acetate = 50:1, concentrated rinse,Intermediate M2-c (6.6 g, 84.6% yield) was obtained.
According to the analysis of related databases, 112671-42-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Beijing Dingcai Technology Co., Ltd.; Gu’an Dingcai Technology Co., Ltd.; Fan Hongtao; Xing Qifeng; Zhang Wei; Zhang Xianghui; (38 pag.)CN107880049; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com