Some common heterocyclic compound, 59528-27-7, name is (4-Iodophenyl)methanamine hydrochloride, molecular formula is C7H9ClIN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of (4-Iodophenyl)methanamine hydrochloride
2,4-dichloro-5-methylpyrimidine (0.300 g, 1.84 mmol) and 4- iodobenzylamine, HC1 (0.496 g, 1.84 mmol) were dissolved in chloroform (4 mL). Triethylamine (0.770 mL, 3.00 mmol) was added and the sealed tube was heated at 60 C overnight. The reaction was purified directly by flash column chromatography (gradient elution with 0- 100% ethyl acetate/hexane) to yield pure 2-chloro-5-methyl-N-(4- iodobenzyl)pyrimidin-4-amine (0.365 g, 1.02 mmol, 55%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 59528-27-7, its application will become more common.
Reference:
Patent; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; UNIVERSITY OF DELAWARE; MALONEY, David J.; ROSENTHAL, Andrew S.; JADHAV, Ajit; DEXHEIMER, Thomas S.; SIMEONOV, Anton; ZHUANG, Zhihao; LIANG, Qin; LUCI, Diane K.; WO2014/105952; (2014); A2;,
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