Application of 101066-87-9, The chemical industry reduces the impact on the environment during synthesis 101066-87-9, name is 4-Iodo-2-(trifluoromethyl)benzonitrile, I believe this compound will play a more active role in future production and life.
Step C. 4-(lH-pyrazol-4-yl)-2-(trifluoromethyl)benzonitrile A mixture of 4-(4,4,5,5-tetramethyl-l ,3,2-dioxaborolan-2-yl)-lH-pyrazole (CAS: 269410- 08-4, Sigma- Aldrich) (300 mg, 1.55 mmol), 4-iodo-2-(trifluoromethyl)benzonitrile (300 mg, 1.01 mmol), Pd(PPh3)4 (18.6 mg, 0.016 mmol), K2C03 (891 mg, 6.46 mmol), and water (2 mL) in 1 ,4-dioxane (10 mL) under nitrogen was heated at 90 C overnight. The reaction mixture was concentrated under reduced pressure. The residue was purified by silica gel chromatography using petroleum ether :EtO Ac (1 : 1) as eluting solvents to afford 4-(lH-pyrazol-4-yl)-2-(trifluoromethyl)benzonitrile as a white solid (203 mg, 84%). LCMS (ESI) m/z: 238.1 [M+H]+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Iodo-2-(trifluoromethyl)benzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BEAUFOUR-IPSEN (TIANJIN) PHARMACEUTICAL CO., LTD.; AUVIN, Serge; LANCO, Christophe; DUTRUEL, Oliver; CHAO, Qi; GU, Kaichun; WO2015/100617; (2015); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com