Synthetic Route of 58313-23-8, The chemical industry reduces the impact on the environment during synthesis 58313-23-8, name is Ethyl-3-iodobenzoate, I believe this compound will play a more active role in future production and life.
General procedure: A mixture of an appropriate unnatural amino acid carboxamide 6 (0.15-0.2 mmol, 1 equiv), an appropriate aryl iodide (5 equiv), Pd(OAc)2 (10 mol%) and AgOAc (2.5 equiv) in anhydrous toluene (2-3 mL) was heated at 110 C for 15-24 h under a nitrogen atm or in a sealed tube. After the reaction period, the reaction mixture was concentrated under reduced pressure to afford a crude reaction mixture, which was purified by column chromatography on neutral alumina or silica gel (eluent EtOAc:hexane) to give the corresponding arylated amino acid (see the respective Schemes/Tables for the specific entries). 3.4.18. Ethyl 3-(1-(1,3-dioxoisoindolin-2-yl)-4-oxo-4-(quinolin-8-ylamino)butan-2-yl)benzoate (8u). The compound 8u was obtained after purification by column chromatography on silica gel (EtOAc:hexane 40:60) as a colourless solid (59 mg, 77%); Rf (40% EtOAc/hexane) 0.3; mp: 142-144 C; IR (DCM): 3054, 2986, 1713, 1266, 743 cm-1; 1H NMR (400 MHz, CDCl3): dH 9.72 (1H, br. s), 8.80-8.79 (1H, m), 8.45 (1H, d, J 7.5 Hz), 8.12-8.10 (2H, m), 7.92 (2H, d, J 7.6 Hz), 7.67-7.62 (3H, m), 7.56 (2H, dd, J1 5.6, J2 3.0 Hz), 7.46-7.33 (4H, m), 4.37 (2H, q, J 7.1 Hz), 4.10-3.97 (3H, m), 3.08-2.97 (2H, m), 1.39 (3H, t, J 7.1 Hz); 13C NMR (CDCl3, 101 MHz): dC 168.9, 168.3, 166.4, 148.1, 141.3, 138.1, 136.2, 134.1, 133.8, 132.6, 131.8, 131.0, 128.8, 128.6, 127.7, 127.2, 123.1, 121.6, 121.4, 116.2, 61.0, 43.1, 41.8, 40.8, 14.4; HRMS (ESI) calcd for C30H26N3O5 [MH] 508.1872 found 508.1847.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl-3-iodobenzoate, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Tomar, Radha; Bhattacharya, Debabrata; Babu, Srinivasarao Arulananda; Tetrahedron; vol. 75; 17; (2019); p. 2447 – 2465;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com