Some common heterocyclic compound, 31827-94-8, name is 2-Bromo-1-(4-iodophenyl)ethanone, molecular formula is C8H6BrIO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: iodides-buliding-blocks
General procedure: Thiosemicarbazone 3 (0.317 g, 1.0 mmoles) was added to astirred solution of 2-bromo-1-(4-fluorophenyl)ethanone(0.217 g, 1.0 mmole) in DMF/EtOH (3: 2) (50 ml). Thereaction mixture was stirred under room temperature for 2 h,and separate precipitate was collected by filtration, suspendedin water and neutralized with NaHCO3 solution.The crude product was purified on silica gel column chromatography(230-400 mesh) using (dichloromethane/methanol, 80:20, Rf = 0.74) to afford the desired product:0.38 g, 87%
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 31827-94-8, its application will become more common.
Reference:
Article; ??czkowski, Krzysztof Z.; Anusiak, Joanna; ?witalska, Marta; Dzitko, Katarzyna; Cytarska, Joanna; Baranowska-??czkowska, Angelika; Plech, Tomasz; Paneth, Agata; Wietrzyk, Joanna; Bia?czyk, Joanna; Medicinal Chemistry Research; vol. 27; 4; (2018); p. 1131 – 1148;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com