Related Products of 19094-56-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19094-56-5 name is 2-Chloro-5-iodobenzoic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Charged 2-chloro-5-iodobenzoic acid (200 gm, 0.7080 moles), dichloromethane(1000 ml) and N,N-dimethylformamide (5 ml) at 25C to 30C. Under stirring slowly charged oxalyl chloride (107.9 gm, 0.8496 moles) and maintained stirring for one hour. Applied cooling and cooled the reaction mass to -15C to -10C. Charged aluminum chloride (113.29gm, 0.8496 moles) maintaining the reaction mass temperature at -10C to -5C and stirred for 30 minutes. Charged phenatole (86.49gm, 0.7080 moles) to the reaction mixture and maintained under stirring for 2 hours at -10C to -5C. The progress of the reaction was monitored by HPLC. After completion of the reaction the reaction mixture was quenched by adding water and dilute hydrochloric acid. Raised the temperature of the reaction mixture to 25C to 30C and maintained for 30 minutes. Separated the organic layer, extracted the aqueous layer again with dichloromethane (400 ml). The combined organic layer was washed with 10% of sodium bicarbonate solution (600 ml) followed with 5% brine solution (600 ml). Concentrated the organic layer under reduced pressure maintaining temperature below 45C to get the residual mass. Charged methanol (1000 ml), heated to reflux and maintained for 3 hours. Cooled the reaction mass to 25C – 30C, filtered the solid and dried till constant weight to get (2-chloro-5 -iodophenyl)(4-ethoxyphenyl)methanone.Yield = 201 gm (73.47%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Chloro-5-iodobenzoic acid, and friends who are interested can also refer to it.
Reference:
Patent; INDOCO REMEDIES LIMITED; KUDUVA, Srinivasan Subramanian; DESHMUKH, Sandip Kacharu; RAMESAN, Palangat Vayalileveetil; PANANDIKAR, Aditi Milind; (25 pag.)WO2018/142422; (2018); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com