Adding a certain compound to certain chemical reactions, such as: 627-32-7, name is 3-Iodo-1-propanol, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 627-32-7, Recommanded Product: 3-Iodo-1-propanol
K2CO3 (118mg, 0.86mmol), NaHCO3 (115mg, 1.36mmol) and, 3-iodo-1-propanol (0.06mL, 0.59mmol) were added to a solution of amine 19 (75mg, 0.39mmol) in acetone (4mL). The reaction mixture was heated to reflux. After 6h, the reaction was cooled to room temperature and the solvent was removed in vacuo. The reaction mixture was purified by chromatography (silica gel, gradient from CH2Cl2 to 95:5 CH2Cl2/MeOH) to afford compound 21 (66mg, 67%) as a brown solid; mp 85-87C; 1H NMR (400MHz, CDCl3) delta 3.77 (m, 2H), 3.13-3.00 (m, 2H), 2.66 (d, J=16.5Hz, 1H), 2.49 (dd, J=17.1, J=6.6Hz, 1H), 2.30-2.07 (m, 6H), 1.92 (m, 1H), 1.79 (m, 1H), 1.73-1.58 (m, 5H), 1.57-1.47 (m, 3H), 1.47-1.29 (m, 2H); 13C NMR (100MHz, CDCl3) delta 212.6, 64.5, 59.5, 48.5, 46.9, 44.3, 42.2, 39.0, 38.1, 35.8, 32.9, 27.8, 26.1, 25.6, 19.6; HRMS (ESI): m/z calcd for C15H26NO2 [M+H]+: 252.1958, found: 252.1962; FTIR (neat) numax: 3384, 2931, 2874, 1703, 1468, 1443, 1416, 1336, 1253, 1231, 1172, 1125, 1111, 1067, 733cm-1.
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Reference:
Article; de Miguel, Irene; Velado, Marina; Herradon, Bernardo; Mann, Enrique; Tetrahedron; vol. 72; 31; (2016); p. 4617 – 4625;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com