Application of 63131-30-6, A common heterocyclic compound, 63131-30-6, name is Ethyl 3-(4-iodophenyl)-3-oxopropanoate, molecular formula is C11H11IO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a solution of ethyl 3-oxo-3-(p-tolyl)propanoate (320 mg, 1.552 mmol) in dry DMF (3.1 mL) was added K2CO3 (236 mg, 1.707 mmol) followed by a solution of propargyl bromide in PhMe (9.2 M, 0.202 mL, 1.862 mmol). The reaction mixture was allowed to stir at ambient room temperature for 12 h. The reaction was transferred to a separatory funnel and diluted with deionized water (20 mL) and the aqueous layer was extracted with ethyl acetate (3 * 20 mL). The combined organic layers were sequentially washed with deionized water (20 mL) and brine (20 mL). The organic layer was dried over sodium sulfate then concentrated in vacuo. The crude material was then purified by flash column chromotography (3% EtOAc/Hexanes) to provide 10 (313 mg, 82%) as a yellow oil.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Golonka, Alexander N.; Schindler, Corinna S.; Tetrahedron; vol. 73; 29; (2017); p. 4109 – 4114;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com