Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 148836-41-3, name is 1-Bromo-4-chloro-2-iodobenzene, A new synthetic method of this compound is introduced below., Quality Control of 1-Bromo-4-chloro-2-iodobenzene
Step B: Preparation of l -Bromo-4-chloro-2-(3,3,3-triethoxyprop- l -ynyl)benzene; [08941 lambda mixture of l -bromo-4-chloro-2-iodoben/cne ( 1 0 g. 32 mmol) in 100 mL degassed ACN and TEA (29 g. 284 mmol), was treated with 3.3,3- triethoyprop- l -ync (6.0 g, 35 mmol), copper(l) iodide (0.60 g. 3.2 mmol), and dichltheta.Obis(triphenylphosphine)palladium(H) ( 1. 1 g, 1 .6 mmol). The mixture was stirred at room temperature for 2 hours at room temperature (the mixture turned dark green after 5 minutes). TLC showed that all starting material was converted, and a new spot was produced. The mixture was concentrated in vacuo. The residue was diluted with 100 ml. ether, washed with H2O (2 20 mL), 5% ammonia water (2 x 20 ml.), brine (20 ml.), dried over anhydrous Na2SO4, and concentrated in vacuo. The crude product was purified by column chromatography pretreated with TEA and eluted with 0-15 % EtOAc/hexane to give 7.6 g of the product as a pale yellow oil. The oil solidified after it was stored in the refrigerator.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; AMGEN INC.; WO2008/76427; (2008); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com