Reference of 847685-01-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 847685-01-2, name is 4,5-Difluoro-2-iodoaniline belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: To a stirred solution of aniline 1(2 mmol) and alkyne 2 (3 mmol) in MeCN (12 mL) were added Pd(PPh3)2Cl2 (56 mg, 0.08 mmol), CuI (34 mg,0.18 mmol) and Et3N (3 mL) at room temperature under an argon atmosphere. The reaction mixture was stirred at 60 C for 2 h. After the mixture was cooled to room temperature, diluted with CH2Cl2(10 mL), poured into H2O (40 mL) and extracted with CH2Cl2(3 × 50 mL). The combined organic layers were washed with H2O (30mL) and dried (MgSO4). After evaporation of the solvent in vacuo,the crude product 3 was obtained (the 1H and19FNMR spectra closely agree with the literature data [2]) and used further without purification.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4,5-Difluoro-2-iodoaniline, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Politanskaya, Larisa; Shteingarts, Vitalij; Tretyakov, Evgeny; Potapov, Alexander; Tetrahedron Letters; vol. 56; 39; (2015); p. 5328 – 5332;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com