Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 608-28-6, name is 2-Iodo-1,3-dimethylbenzene, A new synthetic method of this compound is introduced below., Computed Properties of C8H9I
General procedure: n-BuLi (0.63 mmol, 2.12 M solution in hexanes) was added dropwise to a solution of the alkyne (0.60 mmol) in THF (1.0 mL) at -78 C. The resultant solution was stirred for 30 min, whereupon a solution of ZnBr2 (0.63 mmol) in THF (0.65 mL) was added. The cooling bath was removed, and the solution was warmed to ambient temperature. The aryl iodide (0.30 mmol), PEPPSI-IPr (0.009 mmol), and LiBr (0.90 mmol) were placed into a dry, 10 mL glass sleeve. The sleeve was placed into the metal jacket of the stainless steel pressure reactor, fitted with a rubber septum, and placed under nitrogen. NMP (2 mL) was added, and the mixture was cooled to -78 C, whereupon the previously prepared zinc acetylide solution (2 mL, 0.3 M) was added dropwise. The jacket was removed from the bath, and the pressure reactor was sealed. The reactor was evacuated and backfilled with CO(g) (three cycles, 60 psi). The reactor was heated to 80 C (oil bath) with stirring for 24 h at 60 psi of CO(g). The reaction mixture was diluted with CH2Cl2 (20 mL) and brine (20 mL). The layers were separated, and the aqueous layer was extracted with CH2Cl2 (2×10 mL). The combined organics were dried (MgSO4), filtered, and concentrated under reduced pressure. The crude residue was purified by flash column chromatography, eluting with the indicated solvent to deliver the desired ketone.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; O’Keefe, B. Michael; Simmons, Nicholas; Martin, Stephen F.; Tetrahedron; vol. 67; 24; (2011); p. 4344 – 4351;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com